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MASH improvement (no fibrosis worsening) at 2.4mg: 47% MASH improvement (no fibrosis worsening) at 4.8mg: 62% MASH improvement (no fibrosis worsening) at 6.0mg: 43% Placebo MASH improvement: 14% Liver fat reduction of 30%+ at 4.8mg: 67% Fibrosis improvement by 1+ stage: 34-36% These results led to FDA Breakthrough Therapy designation, which accelerates the development and review process for drugs addressing serious conditions
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While dramatic improvements were reported, some symptoms tended to remain
This led to a theory that GLP-1 may be important for the development of hair follicles
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