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P = .08) and also at 24 weeks (38% vs
7 In more resistant cases, elevations in markers such as IL-6, TNF-alpha, granulocytes, and increased microglial activity have been reported
If confirmed, treatment with semaglutide should not be restarted Gallbladder problems : Rapid weight loss can increase the risk of gallstones, which may cause right upper abdominal pain, fever, or yellowing of the skin/eyes (jaundice) Diabetic retinopathy complications : Patients with existing eye disease should be monitored closely, especially during periods of rapid improvement in blood glucose control [22] [23] Acute kidney injury : Usually associated with severe dehydration from gastrointestinal side effects Allergic reactions, though rare, can occur and may present as rash, itching, or difficulty breathing
While not directly cardiac, this represents an important safety consideration
When GLP-1 is released, it does four main things in the body: Signals the pancreas to release insulin when blood sugar is elevated Suppresses the release of glucagon (a hormone that raises blood sugar) Slows the rate at which food leaves the stomach Acts on appetite centres in the brain to promote feelings of fullness The GLP-1 your body produces gets broken down within a couple of minutes of being released
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