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This article walks through how GLP-1 therapy works, the benefits and risks for seniors specifically, who may need to avoid it, and the strategies that make it safer
In HG-induced models of human renal cortical epithelial cells (HRCApiC) and human renal proximal tubular epithelial cells (HRPTEpic), metformin restored Parkin protein expression and mitophagy through protein phosphatase (PP2A) activation, and inhibited NF-B activation, thereby reducing apoptosis of human renal epithelial cells under high glucose conditions [142]
As these technologies mature, they could offer even more nuanced choices for researchers, further complicating (or simplifying, depending on your perspective) the decision-making process
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GLP-1 may exert its effects locally via the vagus nerve before being degraded by DPP-4 in circulation
