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A thorough and complete history should include: Male infertility risk factors such as a history of bilateral cryptorchidism, vasectomy, chemotherapy or radiation treatments, and chemical exposures Female infertility risk factors, including advanced female age (over 35 years) Reproductive history (Table 2) coital frequency and timing duration of infertility and prior fertility childhood illnesses and developmental history systemic medical illnesses (e.g., diabetes mellitus and upper respiratory diseases) sexual history including sexually transmitted infections gonadal toxin exposure including heat and testosterone Surgical history (with a focus on genitourinary and inguinal surgery) A review of medications (prescription and non- prescription) as many drugs can contribute to infertility Lifestyle exposures such as alcohol, marijuana, and tobacco use as well as vocational exposures Family reproductive history Physical exam As mentioned before, the physical exam is very important in the workup of a man with infertility, with particular focus on the genitourinary exam

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Dosing Protocols in Published Literature Published protocols describe subcutaneous injection of epitalon at 5 to 10 mg per day for 10 to 20 consecutive days, with cycles repeated every 4 to 6 months 1