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For example, a study conducted by Hsieh et al
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However, the largest Phase IIb trial involving 536 subjects failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading Metabolic Pharmaceuticals to terminate development in 2007
A typical nasal TB-500 protocol might use 500-1000mcg daily during loading phases, dropping to 250-500mcg daily for maintenance
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