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Circ Res 90:966973 Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C et al (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
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During periods of high metabolic demand, intense physical exertion, or cellular stress, the mitochondria can become overwhelmed by partially processed metabolic byproducts, specifically excess acetyl-CoA
