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Conversely, CB2, diacylglycerol lipase (DAGL-), monoacylglycerol lipase (MAGL), and other CB2-related genes and proteins which contribute to anti-obesity effects by reducing food intake (Rossi et al., 2018), were elevated by SA/GSGE treatment (Figures 6, 7)

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This enzymatic stimulation appears tissue-specific, as Epithalon selectively protected aged human pinealocytes from degenerative changes while promoting functional restoration of the gland's secretory capacity