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This perspective has shifted substantially over the past 2 decades as accumulating evidence has demonstrated that both tissues secrete bioactive peptides that function as hormones, influencing glucose metabolism, energy expenditure, reproductive physiology, and aspects of aging

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The evidence is extremely weak for a genuine effect in this instance A useful remark in the accompanying editorial is Khouri et al showed a wide variability of results coming from disproportionality analyses, depending both on the method and model specifications, thus opening the door for a selective reporting of results

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