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Although less commonly reported than injection site reactions, some individuals discuss temporary digestive symptoms while using BPC-157

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Second, the cycling recommendation, 8-12 weeks on followed by a 4-week off period, is based on the general principle applied to peptide therapies to prevent receptor desensitization and to allow assessment of lasting effects, rather than on direct MOTS-c cycling data

(PubMed) Lippman SM, Klein EA, Goodman PJ, et al