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Research indicates that the co-existence of PCOS and MASLD increases the likelihood of developing type 2 diabetes, cardiovascular disease, and chronic kidney disease, which are more serious and difficult to manage than MASLD alone ( Therefore, metformin has demonstrated efficacy in the management of PCOS in conjunction with MASLD, particularly in overweight and obese females with PCOS and IR

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K.HattoriS.-i.et al