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Theres limited evidence that semaglutide directly alters sex hormone levels, but weight loss from the drug may help normalize hormone levels, especially in individuals with obesity-related hormone imbalances

doi.org/10.1016/S0140-6736(23)01053-X Knerr, P

Semaglutide, by contrast, activates GLP-1 receptors in your pancreas, brain, and gut to regulate blood sugar, reduce appetite, and slow gastric emptying

And so these are much, much less regulated or not regulated at all, and it's hard to know exactly what you're getting

At the start of the ATTAIN-MAINTAIN study, they had a mean waist circumference of 100.3 cm (s.e.m