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Richardson, S

This medication helps mimic natural hormones to regulate appetite, control blood sugar, and support overall metabolic function

The prevalence of hyperkalemia was 7.6%

The primary pathways for clearing L-OOHs in ferroptosis are the cystine/glutamate antiporter system-glutathione-glutathione peroxidase 4 axis (System Xc-/GSH/GPX4 axis), the ferroptosis suppressor protein 1-coenzyme Q10-nicotinamide adenine dinucleotide phosphate axis (FSP1/CoQ10/NADPH axis), and the GTP cyclohydrolase 1-tetrahydrobiopterin-dihydrofolate reductase axis (GCH1/BH4/DHFR axis) (Figure 1C)

While current pricing remains a barrier for many Canadians, the combination of upcoming generic availability, manufacturer competitive responses, and evolving insurance coverage suggests that this medication will become increasingly accessible