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Its Phase 3 weight-loss figures (in the low-to-mid 20% range) and its late-2025 FDA filing belong to the combination product, not to standalone cagrilintide, which remains at the Phase 2 stage with a peer-reviewed monotherapy result of about 10.8% at 26 weeks
10.18632/oncotarget.25794 29
Expanding therapeutic indications and strong cardiovascular outcome evidence are transforming long-acting GLP-1 analogues into comprehensive metabolic disease therapies rather than diabetes-only treatments
In contrast, circulatory vitamin B12 levels did not exceed the borderline threshold at any time following the conventional Mecogen SL B12 formulation, despite a significant increase from day 3 to day 7 compared to baseline ( p 0.038) (Figure 3 boxplots, top-right)
They should mainly be used as second-line therapy as add on to metformin in patients with type 2 diabetes who have no pre-existing cardiovascular disease and have a therapeutic goal to avoid hypoglycaemic events
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