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CMS indicated that patients with type 2 diabetes, moderate-to-severe obstructive sleep apnea, or MASH are excluded from the Bridge because those are currently Part D-coverable indications
Such difference may arise from the subtle changes in pocket residues at 3.37b (H268 for GLP-2R, Q234 for GLP-1R and Q232 for GCGR), 3.40b (V271 for GLP-2R, V237 for GLP-1R and I235 for GCGR) and ECL2 (N334 for GLP-2R, R299 for GLP-1R and N298 for GCGR)
Conclusion GLP-1 agonists have revolutionized weight loss with effective, science-backed solutions
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J Xenobiot
