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The standard dose schedule takes 12 to 16 weeks to reach the 12mg maintenance dose, following a 4-week escalation pattern through 2mg, 4mg, 8mg, and 12mg

We excluded patients with bariatric surgery history and required weight measurements during baseline (90 days pre-treatment), the first year post-treatment (year 1), and the second year post-treatment (year 2), yielding 34,143 semaglutide-treated and 16,034 tirzepatide-treated patients ( Figure S1 )

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This explains why patients feel symptoms even when they haven't eaten

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