The bioavailability difference only matters for oral, nasal, and topical routes of administration
Role of Ascorbate in the Generation of Endogenous Oxalate Oxalate is present in many foods such as spinach, chard, nuts, black pepper, poppy seeds, and also occurs as a result of the metabolism of ascorbic acid, and the amino acids glycine, serine, and 4-hydroxyproline as well as metabolism of ethanolamine
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Hasan AA, von Websky K, Reichetzeder C, et al
Given the role of insulin, growth hormone, and sex steroids in pubertal maturation, pharmacological modulation of appetite and energy balance during this window may theoretically influence musculoskeletal development, bone mineralization, and long-term metabolic health