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Lower pools of reduced glutathione have been associated with the severity of the autoimmune response, cell apoptosis (death), and autoantibody production

In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

2.1.2 Chemotherapeutics Chemotherapeutic agents undergo oral and parenteral administration and are carried to various tissues via the bloodstream, partitioning into plasma water, plasma proteins, or cells

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Various clinical studies have been done which have highlighted the benefits of milk thistle for various health conditions