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In PsO, clinical studies evaluating GLP-1RAs such as liraglutide and semaglutide have reported significant improvements in PASI scores and histopathological skin features, effects that appear to be at least partially independent of weight loss (50, 53, 54)

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Tesamorelin appears to mediate the positive influence of GHRH and other GHRH analogs such as GRF (1-29), CJC-1295, and Sermorelin

Summary: Swollen lymph nodes are not a recognised side effect of GLP-1 receptor agonists and typically have alternative causes requiring clinical evaluation

Accordingly, the metabolic consequences of GLP-1RA therapy cannot be inferred solely from improvements in inflammatory tone or glycemic control