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2) The study conducted by the research team of Li et al meticulously delineated the role of FOXO4 in Leydig cell senescence and its impact on male fertility, while also demonstrating the therapeutic efficacy of FOXO4-DRI in alleviating age-related testosterone and spermatogenesis insufficiencies

Melatonin has been reported to bind KEAP1, thereby disrupting this interaction and permitting NRF2 to translocate to the nucleus where it can activate antioxidant response element (ARE)-driven gene expression (25, 41, 62, 63)

doi: 10.3389/fpls.2021.668029 Received 15 February 2021 Accepted 21 May 2021 Published 22 July 2021 Volume 12 - 2021 Edited by Md Tabibul Islam, Virginia Tech, United States Reviewed by Anket Sharma, University of Maryland, College Park, United States