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Interest broadened sharply after Yang and colleagues (Cell, 2014) used targeted metabolomic profiling across twelve ferroptosis-inducing small molecules and found that glutathione depletion converges on inactivation of the selenoenzyme glutathione peroxidase 4, placing glutathione availability directly upstream of iron-dependent lipid peroxidation
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Finally, research from March 2025 indicates that undertaking regular moderate-to-vigorous exercise could help lower the risk for neuropsychiatric diseases, including depression
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