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10.1172/JCI111682
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Oxidized PAC-quinone imine metabolites have also been shown to form GSH-conjugates which inhibit glutathione reductase (GR): the decreased activity of GR hampers the detoxification and antioxidant capacity of the GSH-GSSG cycle, further aggravating the pro-oxidative status in the cell (Ndlov et al., 2014)
Its proven efficacy in both electrophysiological and cellular models makes DSIP a versatile peptide for sleep-architecture and neuroprotection studies
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