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In December 2017, semaglutide was officially approved in the United States, and a couple of months later, it was allowed for sale in the European Union

Ninjurin-1, a membrane protein, is also activated upon their formation (161, 162)

This distinction has significant implications for therapeutic strategies

Although both semaglutide and cagrilintide induce satiety, they exert their effects in different regions of the brain, suggesting a synergistic effect on appetite regulation, warranting the investigation of these drugs as a combination therapy

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