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Disclosure of the metabolic retroversion of trimethylamine N-oxide in humans: a pharmacogenetic approach

We found that, after the energy-fixed breakfast, GLP-1 markedly enhanced satiety and fullness compared with placebo (Fig

Packer M, Anker SD, Butler J, Filippatos G, Pocock SJ, Carson P, Januzzi J, Verma S, Tsutsui H, Brueckmann M, Jamal W, Kimura K, Schnee J, Zeller C, Cotton D, Bocchi E, Bhm M, Choi D-J, Chopra V, Chuquiure E, Giannetti N, Janssens S, Zhang J, Gonzalez Juanatey JR, Kaul S, La Brunner- Rocca H-P, Merkely B, Nicholls SJ, Perrone S, Pina I, Ponikowski P, Sattar N, Senni M, Seronde M-F, Spinar J, Squire I, Taddei S, Wanner C, Zannad F

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They treated the subjects with 200 mg per day of a sublingual formulation of glutathione