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These species exist largely in a deprotonated anionic form at physiological pH, while most biothiols exist largely in a neutral protonated form (e.g., the p K a values of glutathione persulfide (GSSH) and glutathione (GSH) were reported to be 5.45 and 8.94, respectively) (Figure 1A) (Figure 1B) (Park et al., 2015)

Rubenstein & Merzenich, 2003) involving either or both upregulated glutamatergic excitatory and down-regulated GABAergic inhibitory systems(Sohal & Rubenstein, 2019)

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