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The constant switching prevents the body from establishing a predictable rhythm and makes side effects harder to manage
Reduction of GSSG to two moles of GSH is the function of glutathione reductase, an enzyme that requires coupled oxidation of NADPH
GLS is frequently overexpressed in various types of cancer, including TNBC, NSCLC, and acute myeloid leukemia ( Therefore, inhibiting Gln degradation by downregulating the expression of these enzymes may represent a novel strategy for cancer treatment
doi: 10.3390/nu17061010
It can be present in two forms, a reduced (GSH) or oxidized (GSSG) form, which help it neutralize dangerous free radicals present in the body
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