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Garcia-Echeverria et al (2004) presented a new compound (a pyrrolo[2,3-d] pyrimidine) that although inhibiting the IGF-1R and IR TK equipotently in cell-free systems, exhibited several-fold selectivity for the IGF-1R in a cellular context and reduced the growth of IGF-1R positive fibrosarcomas in vivo
documented that MTX caused significant elevations in the activities of aminotransferases, levels of creatinine and malondialdehyde (MDA) and a significant decline in the activities of catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase1 (SOD1) and the level of glutathione (GSH)
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