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CHAC1-mediated GSH degradation in the matrix supports FeS cluster proteins and electron transport (Ward et al., 2024)

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Glutathione (GSH) is a tripeptide molecule made from three amino acids: Cysteine (rate-limiting amino acid-contains sulfur) Glycine Glutamate It exists in two forms: Reduced glutathione (GSH) : Active form, the antioxidant Oxidized glutathione (GSSG) : Inactive form, created when GSH neutralizes free radicals The GSH:GSSG ratio is a critical marker of oxidative stress

and Perrino, C

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