Fatigue was not identified as a frequent side effect in clinical trials, occurring in less than 5% of participants
Rohm TV, Meier DT, Olefsky JM, Donath MY (2022) Inflammation in obesity, diabetes and related Disorders
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First, for generalizability to real-world practice, we identified a real-world representative cohort of T2D patients who were GLP-1RA and insulin users in the analyses and implemented a rigorous matching algorithm to match on a range of baseline patient characteristics (demographics, comorbidities, diabetes severity, concurrent medications) to achieve a greater level of between-group comparability
The CVOT for tirzepatide (SURPASS-CVOT) began in May 2020 and is still ongoing