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in consistency with Steinberg et al
The increased amount of GABA then downregulates the GABA receptors, making the net effect less of an inhibitory signal.[ref] GABA can also be metabolized into creatine, and an increase in both GABA and creatine is found in people with dysfunction in the ALDH5A1 gene
Starting at lower doses and increasing gradually reduces the likelihood of systemic effects
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The Source: The information for this story was provided by the National Institutes of Health and the study titled: A brain reward circuit inhibited by next-generation weight-loss drugs in mice, published May 6, 2026 in Nature
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