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However, the clinical development of some ultra-potent DNA-intercalators like the pyrrolobenzodiazepine (PBD) dimers has been challenged by significant off-target toxicities, potentially related to their persistent DNA damage and the bystander effect [47]

Senescent stimuli endow cells with resistance to apoptosis, which involves high activity of anti-apoptotic molecules, such as BCL2 and BCL-XL, and reduced pro-apoptotic BAX protein

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