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Injecting at 8 AM Los Angeles time when you normally dose at 8 AM New York time means you've waited 3 extra hours, which is pharmacokinetically irrelevant

For patients who have tried GLP-1 medications before and stopped because of side effects, microdosing may be worth discussing with a provider

These include: Nausea (affecting 20-40% of patients initially) Vomiting Diarrhoea Constipation Abdominal discomfort These effects typically arise from delayed gastric emptying and direct effects on the gastrointestinal tract

[1] This modest increase is generally not considered clinically significant for most patients and does not usually require treatment modification

M., Neal, C