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It is always wise to start with a lower dose and work your way up to the full recommended amount
Nodules larger than 4cm are more likely to cause pressure symptoms, but most small nodules (under 1cm) remain completely asymptomatic
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Hosein et al., 2012) didnt display any toxicity profile related to renal dysfunction at dose-limiting toxicity (DLT)
Choi SE et al
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