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Participants receiving the highest dose (12 mg weekly) achieved a mean body weight reduction of approximately 24% over 48 weeks results that exceeded those seen with currently approved agents at the time of publication

To identify ubiquitylation factors required for ZZ1-induced BRD4 BD1 degradation, we performed a fluorescence-activated cell sorting CRISPR screen, testing 713 genes involved in the ubiquitinproteasome system (UPS) 13 (Fig

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For conciseness and clarity of discussion, the clearest examples of fasting C-peptide/glucose-associated and differentially abundant proteins are presented and subdivided by their common biological processes and connecting themes