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Retatrutide's TRIUMPH-4 trial reported nausea in 38.1-43.2% of participants, dysesthesia in 8.8-20.9% (dose-dependent), and discontinuation rates of 12.2-18.2%
In rodent studies, NNMT inhibition was associated with shifts in metabolic substrate utilisation
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One reason for this difference is that there are different kinds of B12 injections, each working for a long time
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