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These mechanisms exhibit significant synergy: AMPK activation not only inhibits lipogenesis and inflammation but also enhances autophagy and antioxidant responses, while lignans modulate bile acid metabolism via FXR/TGR5 agonism, and polysaccharides preferentially target SREBP-mediated lipogenic programmingunderscoring constituent-specific actions within SCFs bioactive matrix

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doi: 10.1016/j.bioactmat.2023.10.002

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