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In silico and in vitro studies show enhanced bioavailability and intracellular access, though no in vivo human studies have yet validated this method [66]

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(2004) Proc Natl Acad Sci U S A 101 : 13163 PubMed: 15333749 Search on PubMedSearch on PubMed Central DOI: Primary Citation Related Structures: 1USB PubMed Abstract: A strategy for rational enzyme design is reported and illustrated by the engineering of a protein catalyst for thiol-ester hydrolysis