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However, despite these trials, BPC-157 lacks FDA approval, raising concerns about its safety and efficacy due to insufficient clinical testing

Interestingly, agmatine, a metabolite produced by the gut bacterium Bacteroides vulgatus was shown to impair ovarian function by inhibiting GLP-1 secretion through activation of the farnesoid X receptor (FXR) (Yun et al., 2024)

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They are usually temporary and improve as the body adjusts to semaglutide