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This obstruction can lead to urine retention within the kidney, increased renal pelvis pressure, tubular dilation, cellular phenotypic transformation, apoptosis, glomerular damage, and interstitial inflammation

But all that aside, the important thing to acknowledge is how incredibly difficult it can be for people with obesity to lose that weight and how few safe options doctors have had to help them, which is why it was such a big deal when these hit the market

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doi: 10.1089/ars.2011.4198