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Introduction Mitochondria are organelles produced by archaea that are required for the production of ATP ( Studies discovered mitochondrial-derived peptide called MOTS-c has been shown to significantly reduce the level of pro-inflammatory factors in mice and increase anti-inflammatory factors and insulin-stimulated glucose treatment rates, as well as glucose homeostasis ( Physiological function of MOTS-c MOTS-c, one of the newly discovered sORF-encoded peptides, is a 16-amino acid polypeptide encoded by the mitochondrial 12S rRNA gene and localized to mitochondria under resting conditions ( Figure 1 ) ( Figure 1 MOTS-c, as a mitochondrial coding regulator, has endocrine-like and nuclear transcriptional regulation on muscle metabolism ( Originally, MOTS-c was identified in the process of genetic and pharmacological screening of metabolic regulation in human cells ( MOTS-c has also been found to be involved in the regulation of nuclear gene expression by binding to transcription factors ( Effects of MOTS-c against diseases MOTS-c and aging Gradually disordered metabolic level is one of the signs of aging, which inhibit the normal physiological function of the body and even lose the ability to take care of themselves ( Studies have shown that the interaction of MOTS-c/NRF2 can improve the expression of mitochondrial protective genes ( MOTS-c and cardiovascular disease Obesity is the main culprit of cardiovascular problems ( Recent studies have shown a protective effect of MOTS-c against cardiac dysfunction and pathological remodeling ( via the activation of the AMPK pathway ( MOTS-c and insulin-resistance Insulin resistance can lead to a decrease in the number and the abnormal morphology of mitochondria in tissue cells, which in turn hinders the synthesis of ATP ( MOTS-c enhances insulin sensitivity throughout the body through muscles ( MOTS-c and inflammation By analyzing the changes in inflammatory cytokines in mices serum, the analgesic effect of MOTS-c licking time was evaluated, as well as its anti-inflammatory effects ( Development and application of MOTS-c With the rapid development of synthetic biology technology, the role of genetic engineering bacteria in the treatment of various diseases has become more and more prominent ( E

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