Indications include: Medically refractory disease not responding to optimized biologic therapy Bowel obstruction from fibrostenotic stricture Intra-abdominal abscess not amenable to percutaneous drainage Complex perianal fistula (seton placement, diversion) Enterocutaneous or enterovesical fistula Dysplasia or cancer in Crohns colitis Free perforation (rare) Nutritional Therapy Exclusive enteral nutrition (EEN) effective for induction in pediatric Crohns
However, it may impact nutritional quality
In Figure 4A, we display anaerobic glycolysis and mitochondrial oxidative phosphorylation with the electron transport chain as the aerobic process
Therefore, there is a physiological basis for using the plasma BDNF as a functional surrogate for brain omega-3 FA levels, unlike the erythrocyte omega-3 FA levels, which are metabolically unrelated to the brain levels
If any side effects are severe, persistent, or significantly affecting quality of life or nutritional intake, contact your GP or prescribing clinician promptly