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Trypsin (TPCK-treated, from bovine pancreas), pepsin (from porcine gastric mucosa), dithiothreitol (DTT), acetaminophen (APAP), HPLC-grade acetonitrile (ACN) and methanol (MeOH), iodoacetamide (IAM), glucose-6-phosphate dehydrogenase (type XV, from baker's yeast), and other chemicals were purchased from Sigma-Aldrich (St

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Vials allow physicians greater flexibility when adjusting doses during treatment, which is particularly valuable during titration when patients may benefit from smaller or more individualized increments

Organizations like the American Diabetes Association stress individualized care

ECVAM Statement on the validity of in-vitro tests for skin irritation