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Considering the positive impact of Nrf2 in ameliorating oxidative stress, a number of bioactive components that exert protective effect against APAP-associated hepatotoxicity have been identified and reported, including caffeic acid that activates the Keap1-Nrf2 antioxidant defense system (Pang et al., 2016), carnosic acid that promotes nuclear translocation of Nrf2 ( via AMP-activated kinase/Akt/glycogen synthase kinase 3 pathway (Wang et al., 2016)

Chen, Z.V

Mitochondrial GPx1 decreases induced but not basal oxidative damage to mtDNA in T47D cells

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BPC-157 is stable in various pH environments due to its short, linear peptide sequence and lack of disulfide bonds