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The dual agonist approach distinguishes tirzepatide from single GLP-1 receptor agonists, potentially offering enhanced metabolic benefits
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and compromised epigenetic regulation of gene expression
Following discussion at its October 2025 meeting, the ACM concluded that the current evidence may support the signal for semaglutide, but not dulaglutide or tirzepatide and recommended a range of risk mitigation strategies. After considering all available evidence, including the ACM advice, we made a final decision on regulatory actions including PI and CMI document updates, and publication of safety communications. MEDICINES ON THE LIST: Trulicity Ozempic Wegovy Mounjaro Saxenda Get the latest news from thewest.com.au in your inbox
CagriSema: GI adverse events affected 79.6% in the CagriSema group vs 39.9% placebo in REDEFINE 1, including nausea, vomiting, diarrhea, constipation, and abd
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