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GLP-1 medications can be highly effective, but for many, cost and access remain significant barriers

The BBB prevents almost 98% of small molecule drugs and nearly all large-molecule therapeutics such as recombinant peptides, proteins, anti-sense agents, and genetic vectors, from reaching the brain [1]

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The calculation method of time-to-onset is the interval between the start time of GLP-1 RAs utilization and the time of AE occurrence (19)