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Consistently, AMPK activator AICAR was attenuated, while PARP-1 over-activation aggravated cholesterol-induced toxicity in INS-1 cells, indicating that in islet cells, PARP-1 also regulates cholesterol efflux through AMPK activation and ABCA1 protein, therefore affecting the GLP-1 protection against cholesterol-induced toxicity

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Rouille, Y., Westermark, G., Martin, S

Many studies have shown that a high-protein diet (typical of Western-style diets) can lead to progressive kidney damage and albumin loss in individuals with suboptimal kidney function

Newstrom H: Nutrients Catalog