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In the SUSTAIN6 trial, semaglutide (a GLP-1RA) significantly increased diabetic retinopathy complications, including vitreous hemorrhage [2], while a recent retrospective cohort study of patients with type 2 diabetes showed that use of GLP-1RAs modestly increased the incident risk of diabetic retinopathy, although sight-threatening diabetic complications including blindness were somewhat lower in patients treated with GLP-1 RAs [5]
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A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice
there is clearly much room for improvement
Pregnant people who are taking these medications for weight loss can safely discontinue the medication under their healthcare providers supervision
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