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Very high B12 blood levels without supplementation can sometimes be a marker of liver, kidney, blood, inflammatory, or other disease and deserve medical interpretation

The most common clinical signs associated with GI diseases are some combination of vomiting, diarrhea, and weight loss

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Studies have found that NNMT expression is significantly elevated in the fat tissue of obese individuals compared to lean controls

In conditions like pyridoxine-dependent epilepsy or isoniazid toxicity, pyridoxine administration replenishes PLP stores, thereby restoring normal neurotransmitter levels and terminating seizures