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Of these, H3K9me2 and H3K9me3 are particularly important and are strongly associated with the formation of heterochromatin, a highly condensed chromatin structure that is transcriptionally silent (Padeken et al., 2022)

Quantitative endpoints, such as MRI-PDFF and histology, can capture subtle yet clinically meaningful changes, whereas ALT/AST and ultrasonography may miss early metabolic improvements

Bourla didn't provide much more details, except that the company has two GLP-1 technology drugs and one non-GLP-1 mechanism in the works

But left unchecked, it can get more uncomfortable

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