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SLU-PP-332 SLU-PP-332 is a synthetic agonist of the estrogen-related receptors (ERR, ERR, ERR)
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doi: 10.1111/pcmr.12862 74 GiriPSPatelSBegumRDwivediM
The addition of glucagon receptor agonism is particularly notable: preclinical evidence and early human data suggest it may increase energy expenditure and promote fat breakdown (lipolysis), potentially offering greater weight reduction than dual agonists alone though the precise contribution of each receptor in humans remains an active area of research
Contrarily, a study with 8 GH-deficient subjects found that IGF-1 administration increased lipid oxidation (being this effect more potent when co-administered with GH), energy expenditure, and insulin resistance [108, 183]
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