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Bibcode:1992Cell...71..107B

The receptor question is itself contentious: integrin V5 has been proposed as a functional receptor mediating irisin effects on bone and adipose tissue, and V3 integrin has been implicated in neuroprotective effects, yet neither has been universally accepted as a bona fide irisin receptor, and the binding affinities reported vary across experimental systems (Kim et al., 2018

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Risk of cancer in patients treated with dipeptidyl peptidase-4 inhibitors: an extensive meta-analysis of randomized controlled trials